Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium

In mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of P. chabaudi and significantly increases survival. Similarly, a short exposure of Plasmodium to cys...

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Pubblicato in:Exp Parasitol
Autori principali: Min-Oo, Gundula, Ayi, Kodjo, Bongfen, Silayuv E., Tam, Mifong, Radovanovic, Irena, Gauthier, Susan, Santiago, Helton, Rothfuchs, Antonio Gigliotti, Roffê, Ester, Sher, Alan, Mullick, Alaka, Fortin, Anny, Stevenson, Mary M., Kain, Kevin C., Gros, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828244/
https://ncbi.nlm.nih.gov/pubmed/20219464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2010.02.009
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