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Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide
Human α-defensin 6 (HD6) is a unique peptide of the defensin family that provides innate immunity in the intestine by self-assembling to form higher-order oligomers that entrap bacteria and prevent host cell invasion. Here, we report critical steps in the self-assembly pathway of HD6. We demonstrate...
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| Veröffentlicht in: | Chem Sci |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4827351/ https://ncbi.nlm.nih.gov/pubmed/27076903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04194e |
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