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Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia

Searching for genetic variants with unusual differentiation between subpopulations is an established approach for identifying signals of natural selection. However, existing methods generally require discrete subpopulations. We introduce a method that infers selection using principal components (PCs...

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Bibliografske podrobnosti
izdano v:Am J Hum Genet
Main Authors: Galinsky, Kevin J., Bhatia, Gaurav, Loh, Po-Ru, Georgiev, Stoyan, Mukherjee, Sayan, Patterson, Nick J., Price, Alkes L.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827102/
https://ncbi.nlm.nih.gov/pubmed/26924531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.12.022
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