The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease

Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca(2+)-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Lee, Soojin, Bang, Se Min, Hong, Yoon Ki, Lee, Jang Ho, Jeong, Haemin, Park, Seung Hwan, Liu, Quan Feng, Lee, Im-Soon, Cho, Kyoung Sang
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826976/
https://ncbi.nlm.nih.gov/pubmed/26659252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018069
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