Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication

VZV IE62 is an essential, immediate-early, tegument protein and consists of five domains. We generated recombinant viruses carrying mutations in the first three IE62 domains and tested their influence on VZV replication kinetics. The mutations in domain I did not affect replication kinetics while do...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Khalil, Mohamed I., Che, Xibing, Sung, Philip, Sommer, Marvin H., Hay, John, Arvin, Ann M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826839/
https://ncbi.nlm.nih.gov/pubmed/26914506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.02.012
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