The zinc-finger domains of PARP1 cooperate to recognise DNA strand-breaks

Poly(ADP-ribose) polymerase I (PARP1) is a primary DNA damage sensor whose (ADP-ribose) polymerase activity is acutely regulated by interaction with DNA breaks. Upon activation at sites of DNA damage, PARP1 modifies itself and other proteins by covalent addition of long branched polymers of ADP-ribo...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Ali, Ammar A.E., Timinszky, Gyula, Arribas-Bosacoma, Raquel, Kozlowski, Marek, Hassa, Paul O., Hassler, Markus, Ladurner, Andreas G., Pearl, Laurence H., Oliver, Antony W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826610/
https://ncbi.nlm.nih.gov/pubmed/22683995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2335
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