Zinc-induced polymerization of killer-cell Ig-like receptor into filaments promotes its inhibitory function at cytotoxic immunological synapses

The inhibitory function of killer cell immunoglobulin-like receptors (KIR) that bind HLA-C and block activation of human natural killer (NK) cells is dependent on zinc. We report that zinc induced the assembly of soluble KIR into filamentous polymers, as detected by electron microscopy, which depoly...

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Pubblicato in:Mol Cell
Autori principali: Kumar, Santosh, Rajagopalan, Sumati, Sarkar, Pabak, Dorward, David W., Peterson, Mary E., Liao, Hsien-Shun, Guillermier, Christelle, Steinhauser, Matthew L., Vogel, Steven S., Long, Eric O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826557/
https://ncbi.nlm.nih.gov/pubmed/27058785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.009
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