RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

We report a mechanism through which the transcription machinery directly controls topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle. By comparing TOP1 occupancy using ChIP-Seq, versus TOP1 activity using TOP1-Seq, a method reported here to map catalytically en...

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Udgivet i:Cell
Main Authors: Baranello, Laura, Wojtowicz, Damian, Cui, Kairong, Devaiah, Ballachanda N., Chung, Hye-Jung, Chan-Salis, Ka Yim, Guha, Rajarshi, Wilson, Kelli, Zhang, Xiaohu, Zhang, Hongliang, Piotrowski, Jason, Thomas, Craig, Singer, Dinah S., Pugh, B. Franklin, Pommier, Yves, Przytycka, Teresa M., Kouzine, Fedor, Lewis, Brian A., Zhao, Keji, Levens, David
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826470/
https://ncbi.nlm.nih.gov/pubmed/27058666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.036
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