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Role of TET enzymes in DNA methylation, development, and cancer

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. T...

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Foilsithe in:Genes Dev
Main Authors: Rasmussen, Kasper Dindler, Helin, Kristian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826392/
https://ncbi.nlm.nih.gov/pubmed/27036965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276568.115
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