Circulating IGF-I and IGFBP3 levels control human colonic stem cell function and are disrupted in diabetic enteropathy

The role of circulating factors in regulating colonic stem cells (CoSCs) and colonic epithelial homeostasis is unclear. Individuals with long-standing type 1 diabetes (T1D) frequently have intestinal symptoms, termed diabetic enteropathy (DE), though its etiology is unknown. Here, we report T1D pati...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: D'Addio, Francesca, La Rosa, Stefano, Maestroni, Anna, Jung, Peter, Orsenigo, Elena, Nasr, Moufida Ben, Tezza, Sara, Bassi, Roberto, Finzi, Giovanna, Marando, Alessandro, Vergani, Andrea, Frego, Roberto, Albarello, Luca, Andolfo, Annapaola, Manuguerra, Roberta, Viale, Edi, Staudacher, Carlo, Corradi, Domenico, Batlle, Eduard, Breault, David, Secchi, Antonio, Folli, Franco, Fiorina, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826279/
https://ncbi.nlm.nih.gov/pubmed/26431183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.07.010
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