EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis

Glioblastoma (GBM) is one of the most lethal brain tumors with a short survival time. EGFR amplification and mutation is the most significant genetic signature in GBM. About half of the GBMs with EGFR amplification express a constitutively autophosphorylated variant of EGFR, known as EGFRvIII. Our i...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Liu, Zhaoyu, Han, Lei, Dong, Yucui, Tan, Yanli, Li, Yongsheng, Zhao, Manli, Xie, Hui, Ju, Huanyu, Wang, He, Zhao, Yu, Zheng, Qifan, Wang, Qixue, Su, Jun, Fang, Chuan, Fu, Songbin, Jiang, Tao, Liu, Jiaren, Li, Xia, Kang, Chunsheng, Ren, Huan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826235/
https://ncbi.nlm.nih.gov/pubmed/26717039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6730
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