Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade

Intrinsic cross-resistance to inhibition of different signaling pathways may hamper development of combinatorial treatments in melanoma, but the relative frequency of this phenotype and the strategies to overcome this hurdle remain poorly understood. Among 49 BRAF-mutant melanoma cell lines from pat...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Penna, Ilaria, Molla, Alessandra, Grazia, Giulia, Cleris, Loredana, Nicolini, Gabriella, Perrone, Federica, Picciani, Benedetta, Del Vecchio, Michele, de Braud, Filippo, Mortarini, Roberta, Anichini, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826182/
https://ncbi.nlm.nih.gov/pubmed/26678033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6600
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