Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease. To this end, chemically modified dendrimer nanomaterials were synthesized and optimized for targeted small interfering RNA (siRNA...

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Gepubliceerd in:Nano Lett
Hoofdauteurs: Khan, Omar F., Zaia, Edmond W., Jhunjhunwala, Siddharth, Xue, Wen, Cai, Wenxin, Yun, Dong Soo, Barnes, Carmen M., Dahlman, James E., Dong, Yizhou, Pelet, Jeisa M., Webber, Matthew J., Tsosie, Jonathan K., Jacks, Tyler E., Langer, Robert, Anderson, Daniel G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825876/
https://ncbi.nlm.nih.gov/pubmed/25789998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl5048972
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