Ionizable amphiphilic dendrimer-based nanomaterials with alkyl chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo

A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle-forming materials was produced wherein the free amines on multigenerational pol...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Khan, Omar F., Zaia, Edmond W., Yin, Hao, Bogorad, Roman L., Pelet, Jeisa M., Webber, Matthew J., Zhuang, Iris, Dahlman, James E., Langer, Robert, Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785599/
https://ncbi.nlm.nih.gov/pubmed/25354018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408221
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