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Ionizable amphiphilic dendrimer-based nanomaterials with alkyl chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo
A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle-forming materials was produced wherein the free amines on multigenerational pol...
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| Publicado no: | Angew Chem Int Ed Engl |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4785599/ https://ncbi.nlm.nih.gov/pubmed/25354018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408221 |
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