Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease. To this end, chemically modified dendrimer nanomaterials were synthesized and optimized for targeted small interfering RNA (siRNA...

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Pubblicato in:Nano Lett
Autori principali: Khan, Omar F., Zaia, Edmond W., Jhunjhunwala, Siddharth, Xue, Wen, Cai, Wenxin, Yun, Dong Soo, Barnes, Carmen M., Dahlman, James E., Dong, Yizhou, Pelet, Jeisa M., Webber, Matthew J., Tsosie, Jonathan K., Jacks, Tyler E., Langer, Robert, Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825876/
https://ncbi.nlm.nih.gov/pubmed/25789998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl5048972
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