Survey of variation in human transcription factors reveals prevalent DNA binding changes

Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human transcription factors (TFs), but the consequences of such variation remain largely unexplored. We developed a computational, structure-based approach to evaluate TF variants for their imp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Barrera, Luis A., Vedenko, Anastasia, Kurland, Jesse V., Rogers, Julia M., Gisselbrecht, Stephen S., Rossin, Elizabeth J., Woodard, Jaie, Mariani, Luca, Kock, Kian Hong, Inukai, Sachi, Siggers, Trevor, Shokri, Leila, Gordân, Raluca, Sahni, Nidhi, Cotsapas, Chris, Hao, Tong, Yi, Song, Kellis, Manolis, Daly, Mark J., Vidal, Marc, Hill, David E., Bulyk, Martha L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825693/
https://ncbi.nlm.nih.gov/pubmed/27013732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad2257
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados