MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the s...

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Bibliographic Details
Published in:G3 (Bethesda)
Main Authors: Chen, Yushu, Bharill, Shashank, O’Hagan, Robert, Isacoff, Ehud Y., Chalfie, Martin
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2016
Subjects:
Mutant Screen Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825646/
https://ncbi.nlm.nih.gov/pubmed/27172609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.023507
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