Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

Relapsed precursor T-cell acute lymphoblastic leukemia is characterized by resistance against chemotherapy and is frequently fatal. We aimed at understanding the molecular mechanisms resulting in relapse of T-cell acute lymphoblastic leukemia and analyzed 13 patients at first diagnosis, remission an...

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Publicado no:Haematologica
Main Authors: Kunz, Joachim B., Rausch, Tobias, Bandapalli, Obul R., Eilers, Juliane, Pechanska, Paulina, Schuessele, Stephanie, Assenov, Yassen, Stütz, Adrian M., Kirschner-Schwabe, Renate, Hof, Jana, Eckert, Cornelia, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Koehler, Rolf, Avigad, Smadar, Elitzur, Sarah, Handgretinger, Rupert, Benes, Vladimir, Weischenfeldt, Joachim, Korbel, Jan O., Muckenthaler, Martina U., Kulozik, Andreas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825305/
https://ncbi.nlm.nih.gov/pubmed/26294725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.129692
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