Ajuga Δ24-Sterol Reductase Catalyzes the Direct Reductive Conversion of 24-Methylenecholesterol to Campesterol

Dimunito/Dwarf1 (DWF1) is an oxidoreductase enzyme that is responsible for the conversion of C(28)- and C(29)-Δ(24(28))-olefinic sterols to 24-methyl- and 24-ethylcholesterols. Generally, the reaction proceeds in two steps via the Δ(24(25)) intermediate. In this study, we characterized the ArDWF1 ge...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Tsukagoshi, Yuki, Suzuki, Hideyuki, Seki, Hikaru, Muranaka, Toshiya, Ohyama, Kiyoshi, Fujimoto, Yoshinori
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825020/
https://ncbi.nlm.nih.gov/pubmed/26872973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703470
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