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Amide Rotation Hindrance Predicts Proteolytic Resistance of Cystine-Knot Peptides
Cystine-knot peptides have remarkable stability against protease degradation, and are attractive scaffolds for peptide-based therapeutic and diagnostic agents. In this work, by studying the hydrolysis reaction of a cystine-knot inhibitor MCTI-A and its variants with ab initio QM/MM molecular dynamic...
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| Veröffentlicht in: | J Phys Chem Lett |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824663/ https://ncbi.nlm.nih.gov/pubmed/26958702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.6b00373 |
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