Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter–Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth

Stromal-epithelial interaction has been shown to promote local tumor growth and distant metastasis. We sought to create a promising gene therapy approach that co-targets cancer and its supporting stromal cells for combating castration-resistant prostate tumors. Herein, we demonstrated that human ost...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sung, Shian-Ying, Chang, Junn-Liang, Chen, Kuan-Chou, Yeh, Shauh-Der, Liu, Yun-Ru, Su, Yen-Hao, Hsueh, Chia-Yen, Chung, Leland W. K., Hsieh, Chia-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824507/
https://ncbi.nlm.nih.gov/pubmed/27054343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153350
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