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Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene expression changes with reactive oxygen species serving as mediators. The evolved stromal cells are highly inductive of human PCa growth in mice, and...

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Detalhes bibliográficos
Main Authors: Sung, Shian-Ying, Hsieh, Chia-Ling, Law, Andrew, Zhau, Haiyen E., Pathak, Sen, Multani, Asha S., Lim, Sharon, Coleman, Ilsa M., Wu, Li-Chin, Figg, William D., Dahut, William L., Nelson, Peter, Lee, Jae K., Amin, Mahul B., Lyles, Robert, Johnstone, Peter A.J., Marshall, Fray F., Chung, Leland W.K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105756/
https://ncbi.nlm.nih.gov/pubmed/19047182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2492
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