Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

The Toll-like receptor (TLR) signaling pathway is activated in synovial fibroblast cells in patients with rheumatoid arthritis (RA). The receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, are key molecules involved in the differentiation of osteoclasts and joint destruction in RA....

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Udgivet i:PLoS One
Main Authors: Watanabe, Tatsuo, Takahashi, Nobunori, Hirabara, Shinya, Ishiguro, Naoki, Kojima, Toshihisa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824426/
https://ncbi.nlm.nih.gov/pubmed/27054952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153142
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