Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts

OBJECTIVE: To explore the effect of hyaluronan oligosaccharides (HAoligos) on interactions between HA and its principal receptor, CD44, in rheumatoid synovial fibroblasts (RSFs) and matrix metalloproteinase (MMP) production. METHODS: RSFs were isolated from rheumatoid synovial tissue. HA distributio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hanabayashi, Masahiro, Takahashi, Nobunori, Sobue, Yasumori, Hirabara, Shinya, Ishiguro, Naoki, Kojima, Toshihisa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001728/
https://ncbi.nlm.nih.gov/pubmed/27564851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161875
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