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Genetic Load of Loss-of-Function Polymorphic Variants in Great Apes

Loss of function (LoF) genetic variants are predicted to disrupt gene function, and are therefore expected to substantially reduce individual’s viability. Knowing the genetic burden of LoF variants in endangered species is of interest for a better understanding of the effects of declining population...

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Bibliografske podrobnosti
izdano v:Genome Biol Evol
Main Authors: de Valles-Ibáñez, Guillem, Hernandez-Rodriguez, Jessica, Prado-Martinez, Javier, Luisi, Pierre, Marquès-Bonet, Tomàs, Casals, Ferran
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824148/
https://ncbi.nlm.nih.gov/pubmed/26912403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evw040
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