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Genetic Load of Loss-of-Function Polymorphic Variants in Great Apes

Loss of function (LoF) genetic variants are predicted to disrupt gene function, and are therefore expected to substantially reduce individual’s viability. Knowing the genetic burden of LoF variants in endangered species is of interest for a better understanding of the effects of declining population...

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Dettagli Bibliografici
Pubblicato in:Genome Biol Evol
Autori principali: de Valles-Ibáñez, Guillem, Hernandez-Rodriguez, Jessica, Prado-Martinez, Javier, Luisi, Pierre, Marquès-Bonet, Tomàs, Casals, Ferran
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824148/
https://ncbi.nlm.nih.gov/pubmed/26912403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evw040
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