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Genetic Load of Loss-of-Function Polymorphic Variants in Great Apes

Loss of function (LoF) genetic variants are predicted to disrupt gene function, and are therefore expected to substantially reduce individual’s viability. Knowing the genetic burden of LoF variants in endangered species is of interest for a better understanding of the effects of declining population...

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Bibliografische gegevens
Gepubliceerd in:Genome Biol Evol
Hoofdauteurs: de Valles-Ibáñez, Guillem, Hernandez-Rodriguez, Jessica, Prado-Martinez, Javier, Luisi, Pierre, Marquès-Bonet, Tomàs, Casals, Ferran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824148/
https://ncbi.nlm.nih.gov/pubmed/26912403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evw040
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