Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection

DNA double-strand breaks (DSBs) are one of the most cytotoxic types of DNA lesion challenging genome integrity. The activity of cyclin-dependent kinase Cdk1 is essential for DSB repair by homologous recombination and for DNA damage signaling. Here we identify the Fun30 chromatin remodeler as a new t...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Chen, Xuefeng, Niu, Hengyao, Yu, Yang, Wang, Jingjing, Zhu, Shuangyi, Zhou, Jianjie, Papusha, Alma, Cui, Dandan, Pan, Xuewen, Kwon, Youngho, Sung, Patrick, Ira, Grzegorz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824098/
https://ncbi.nlm.nih.gov/pubmed/26801641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1544
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