Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential. The mechanisms governing viral fitness in epidemiological settings, however, remain poorly defined. We identified a determinant of fitness in a...

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Publicado en:Science
Main Authors: Manokaran, Gayathri, Finol, Esteban, Wang, Chunling, Gunaratne, Jayantha, Bahl, Justin, Ong, Eugenia Z., Tan, Hwee Cheng, Sessions, October M., Ward, Alex M., Gubler, Duane J., Harris, Eva, Garcia-Blanco, Mariano A., Ooi, Eng Eong
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824004/
https://ncbi.nlm.nih.gov/pubmed/26138103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab3369
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