Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

Metformin, one of the most common prescriptions for patients with type 2 diabetes, is reported to protect the kidney from gentamicin-induced nephrotoxicity. However, the role and mechanisms for metformin in preventing cisplatin-induced nephrotoxicity remains largely unknown. In this study, a single...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Li, Jianzhong, Gui, Yuan, Ren, Jiafa, Liu, Xin, Feng, Ye, Zeng, Zhifeng, He, Weichun, Yang, Junwei, Dai, Chunsun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823749/
https://ncbi.nlm.nih.gov/pubmed/27052588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23975
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