Evidence that a lipolytic enzyme—hematopoietic-specific phospholipase C-β2—promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes

Hematopoietic stem/progenitor cells (HSPCs) reside in the bone marrow (BM) microenvironment and are retained there by the interaction of membrane lipid raft-associated receptors, such as the α-chemokine receptor CXCR4 and the α(4)β(1)-integrin (VLA-4, very late antigen 4 receptor) receptor, with the...

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Publicat a:Leukemia
Autors principals: Adamiak, M, Poniewierska-Baran, A, Borkowska, S, Schneider, G, Abdelbaset-Ismail, A, Suszynska, M, Abdel-Latif, A, Kucia, M, Ratajczak, J, Ratajczak, M Z
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823158/
https://ncbi.nlm.nih.gov/pubmed/26582648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.315
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