Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

Statins purportedly exert anti-tumoral effects on breast cancer. However, the biologic mechanisms for these actions are not fully elucidated. The aims of this study were 1) to explore the effects of simvastatin on apoptosis, proliferation as well as PI3K/Akt/mTOR and MAPK/ERK pathway in a window-of-...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Wang, Tingting, Seah, Serena, Loh, Xinyi, Chan, Ching-Wan, Hartman, Mikael, Goh, Boon-Cher, Lee, Soo-Chin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823053/
https://ncbi.nlm.nih.gov/pubmed/26565813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6304
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker