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Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

Statins purportedly exert anti-tumoral effects on breast cancer. However, the biologic mechanisms for these actions are not fully elucidated. The aims of this study were 1) to explore the effects of simvastatin on apoptosis, proliferation as well as PI3K/Akt/mTOR and MAPK/ERK pathway in a window-of-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Tingting, Seah, Serena, Loh, Xinyi, Chan, Ching-Wan, Hartman, Mikael, Goh, Boon-Cher, Lee, Soo-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823053/
https://ncbi.nlm.nih.gov/pubmed/26565813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6304
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