BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo

BRCA1 mutation is associated with carcinogenesis, especially of breast tissue. Telomere maintenance is crucial for malignant transformation. Being a part of the DNA repair machinery, BRCA1 may be implicated in telomere biology. We explored the role of BRCA1 in telomere maintenance in lymphocytes of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Uziel, Orit, Yerushalmi, Rinat, Zuriano, Lital, Naser, Shaden, Beery, Einat, Nordenberg, Jardena, Lubin, Ido, Adel, Yonatan, Shepshelovich, Daniel, Yavin, Hagai, Aharon, Irit Ben, Pery, Shlomit, Rizel, Shulamit, Pasmanik-Chor, Metsada, Frumkin, Dan, Lahav, Meir
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823046/
https://ncbi.nlm.nih.gov/pubmed/26515461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5693
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