Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription

The ancient, highly conserved, Wnt signaling pathway regulates cell fate in all metazoans. We have previously shown that combined null mutations of the specificity protein (Sp) 1/Klf-like zinc-finger transcription factors Sp5 and Sp8 (i.e., Sp5/8) result in an embryonic phenotype identical to that o...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kennedy, Mark W., Chalamalasetty, Ravindra B., Thomas, Sara, Garriock, Robert J., Jailwala, Parthav, Yamaguchi, Terry P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822596/
https://ncbi.nlm.nih.gov/pubmed/26969725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519994113
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