Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription

The ancient, highly conserved, Wnt signaling pathway regulates cell fate in all metazoans. We have previously shown that combined null mutations of the specificity protein (Sp) 1/Klf-like zinc-finger transcription factors Sp5 and Sp8 (i.e., Sp5/8) result in an embryonic phenotype identical to that o...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Kennedy, Mark W., Chalamalasetty, Ravindra B., Thomas, Sara, Garriock, Robert J., Jailwala, Parthav, Yamaguchi, Terry P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822596/
https://ncbi.nlm.nih.gov/pubmed/26969725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519994113
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