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Dimension reduction and shrinkage methods for high dimensional disease risk scores in historical data

BACKGROUND: Multivariable confounder adjustment in comparative studies of newly marketed drugs can be limited by small numbers of exposed patients and even fewer outcomes. Disease risk scores (DRSs) developed in historical comparator drug users before the new drug entered the market may improve adju...

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Bibliographische Detailangaben
Veröffentlicht in:Emerg Themes Epidemiol
Hauptverfasser: Kumamaru, Hiraku, Schneeweiss, Sebastian, Glynn, Robert J., Setoguchi, Soko, Gagne, Joshua J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822311/
https://ncbi.nlm.nih.gov/pubmed/27053942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12982-016-0047-x
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