Detecting gene-gene interactions using a permutation-based random forest method

BACKGROUND: Identifying gene-gene interactions is essential to understand disease susceptibility and to detect genetic architectures underlying complex diseases. Here, we aimed at developing a permutation-based methodology relying on a machine learning method, random forest (RF), to detect gene-gene...

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Publicat a:BioData Min
Autors principals: Li, Jing, Malley, James D., Andrew, Angeline S., Karagas, Margaret R., Moore, Jason H.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Methodology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822295/
https://ncbi.nlm.nih.gov/pubmed/27053949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13040-016-0093-5
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