Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors

We previously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass in mice. BMPR1B, another BMP type I receptor, is also capable of binding to BMP ligands and transduce BMP signaling. However, little is known about t...

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Publicado no:Sci Rep
Main Authors: Shi, Ce, Iura, Ayaka, Terajima, Masahiko, Liu, Fei, Lyons, Karen, Pan, Haichun, Zhang, Honghao, Yamauchi, Mitsuo, Mishina, Yuji, Sun, Hongchen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822175/
https://ncbi.nlm.nih.gov/pubmed/27048979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24256
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