CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

Rasmussen encephalitis (RE) is a rare paediatric epilepsy with uni-hemispheric inflammation and progressive neurological deficits. To elucidate RE immunopathology, we applied T-cell receptor (TCR) sequencing to blood (n=23), cerebrospinal fluid (n=2) and brain biopsies (n=5) of RE patients, and paed...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Schneider-Hohendorf, Tilman, Mohan, Hema, Bien, Christian G., Breuer, Johanna, Becker, Albert, Görlich, Dennis, Kuhlmann, Tanja, Widman, Guido, Herich, Sebastian, Elpers, Christiane, Melzer, Nico, Dornmair, Klaus, Kurlemann, Gerhard, Wiendl, Heinz, Schwab, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822013/
https://ncbi.nlm.nih.gov/pubmed/27040081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11153
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