Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman primates revealed ambiguous effects of DR on lifespan despite improvements in health parameters. In this study, we analyzed consequences of adult...

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發表在:J Exp Med
Main Authors: Tang, Duozhuang, Tao, Si, Chen, Zhiyang, Koliesnik, Ievgen Oleksandrovich, Calmes, Philip Gerald, Hoerr, Verena, Han, Bing, Gebert, Nadja, Zörnig, Martin, Löffler, Bettina, Morita, Yohei, Rudolph, Karl Lenhard
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821645/
https://ncbi.nlm.nih.gov/pubmed/26951333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151100
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