Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman primates revealed ambiguous effects of DR on lifespan despite improvements in health parameters. In this study, we analyzed consequences of adult...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Tang, Duozhuang, Tao, Si, Chen, Zhiyang, Koliesnik, Ievgen Oleksandrovich, Calmes, Philip Gerald, Hoerr, Verena, Han, Bing, Gebert, Nadja, Zörnig, Martin, Löffler, Bettina, Morita, Yohei, Rudolph, Karl Lenhard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821645/
https://ncbi.nlm.nih.gov/pubmed/26951333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151100
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