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Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation

Hundreds of L1CAM gene mutations have been shown to be associated with congenital hydrocephalus, severe intellectual disability, aphasia, and motor symptoms. How such mutations impair neuronal function, however, remains unclear. Here, we generated human embryonic stem (ES) cells carrying a condition...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Patzke, Christopher, Acuna, Claudio, Giam, Louise R., Wernig, Marius, Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821644/
https://ncbi.nlm.nih.gov/pubmed/27001749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150951
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