Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer

Despite recent improvements in patient outcomes using newer androgen receptor (AR) pathway inhibitors, treatment resistance in castrate resistant prostate cancer (CRPC) continues to remain a clinical problem. Co-targeting alternate resistance pathways are of significant interest to treat CRPC and de...

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Udgivet i:PLoS One
Main Authors: Toren, Paul, Kim, Soojin, Johnson, Fraser, Zoubeidi, Amina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821639/
https://ncbi.nlm.nih.gov/pubmed/27046225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152861
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