The apoptotic engulfment machinery regulates axonal degeneration in C. elegans neurons

Axonal degeneration is a characteristic feature of neurodegenerative disease and nerve injury. Here, we characterize axonal degeneration in Caenorhabditis elegans neurons following laser-induced axotomy. We show that this process proceeds independently of the WLD(S) and Nmnat pathway, and requires t...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Nichols, Annika L. A., Meelkop, Ellen, Linton, Casey, Giordano-Santini, Rosina, Sullivan, Robert K., Donato, Alessandra, Nolan, Cara, Hall, David H., Xue, Ding, Neumann, Brent, Hilliard, Massimo A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821572/
https://ncbi.nlm.nih.gov/pubmed/26876181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.050
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