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In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma
PURPOSE: Epidermal growth factor receptor (EGFR) is usually overexpressed in nasopharyngeal carcinoma (NPC). We tested the antitumor effects of irreversible ErbB family inhibitor afatinib on human NPC using in vitro and in vivo models. MATERIALS AND METHODS: The effect of afatinib on NPC cells was e...
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| Publicado no: | Drug Des Devel Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4821387/ https://ncbi.nlm.nih.gov/pubmed/27099475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S94432 |
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