In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

PURPOSE: Epidermal growth factor receptor (EGFR) is usually overexpressed in nasopharyngeal carcinoma (NPC). We tested the antitumor effects of irreversible ErbB family inhibitor afatinib on human NPC using in vitro and in vivo models. MATERIALS AND METHODS: The effect of afatinib on NPC cells was e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Des Devel Ther
Prif Awduron: Xue, Cong, Tian, Ying, Zhang, Jing, Zhao, Yuanyuan, Zhan, Jianhua, Fang, Wenfeng, Zhang, Li
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2016
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821387/
https://ncbi.nlm.nih.gov/pubmed/27099475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S94432
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