Aberrant DNA Methylation of Phosphodiestarase 4D Alters Airway Smooth Muscle Cell Phenotypes

Airway hyperresponsiveness (AHR) is a hallmark feature in asthma characterized by exaggerated airway contractile response to stimuli due to increased airway sensitivity and chronic airway remodeling. We have previously shown that allergen-induced AHR in mice is associated with aberrant DNA methylati...

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Опубликовано в: :Am J Respir Cell Mol Biol
Главные авторы: Lin, Amanda H. Y., Shang, Yan, Mitzner, Wayne, Sham, James S. K., Tang, Wan-yee
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2016
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821043/
https://ncbi.nlm.nih.gov/pubmed/26181301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0079OC
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