Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model

AIM: Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, has been shown to exert beneficial effects in heart failure. The purpose of this study was to test whether sildenafil suppressed transverse-tubule (T-tubule) remodeling in left ventricular (LV) failure and thereby providing the therapeutic ben...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Huang, Chun-kai, Chen, Bi-yi, Guo, Ang, Chen, Rong, Zhu, Yan-qi, Kutschke, William, Hong, Jiang, Song, Long-sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820805/
https://ncbi.nlm.nih.gov/pubmed/26972492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.13
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