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Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients

AIM: To examine how the endogenous CYP3A4 phenotype and CYP3A5(*)3 genotype of Chinese renal transplant recipients influenced the dose-corrected trough concentration (C(0)/D) and weight-corrected daily dose (D/W) of tacrolimus. METHODS: A total of 101 medically stable kidney transplant recipients we...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Luo, Xi, Zhu, Li-jun, Cai, Ning-fang, Zheng, Li-yun, Cheng, Ze-neng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820801/
https://ncbi.nlm.nih.gov/pubmed/26924289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.163
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