Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway

PRRS is one of the most important diseases in swine industry. Current PRRS inactivated vaccine provides only a limited protection and cannot induce sufficient cell-mediated immune responses. In this study, we first found that the mRNA and protein levels of Th1-type cytokines (IFN-γ, IL-12) and Th2-t...

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Publicat a:Sci Rep
Autors principals: Hu, Yue, Cong, Xiaoyan, Chen, Lei, Qi, Jing, Wu, Xiangju, Zhou, Mingming, Yoo, Dongwan, Li, Feng, Sun, Wenbo, Wu, Jiaqiang, Zhao, Xiaomin, Chen, Zhi, Yu, Jiang, Du, Yijun, Wang, Jinbao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820752/
https://ncbi.nlm.nih.gov/pubmed/27046485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23977
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