Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication

GRP78/BiP is an endoplasmic reticulum (ER) chaperone protein with the important function of maintaining ER homeostasis, and the overexpression of GRP78/BiP alleviates ER stress. Our previous studies showed that infection with enterovirus 71 (EV71), a (+)RNA picornavirus, induced GRP78/BiP upregulati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Emerg Microbes Infect
Prif Awduron: Jheng, Jia-Rong, Wang, Shin-Chyang, Jheng, Chao-Rih, Horng, Jim-Tong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820672/
https://ncbi.nlm.nih.gov/pubmed/27004760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2016.20
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