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Targeting of hexokinase 1 to liver and hepatoma mitochondria.

The proportion of hexokinase (HK; EC 2.7.1.1) isozyme 1 (HK1) that is bound to the outer mitochondrial membrane is tissue specific and developmentally regulated. HK activity is known to be markedly elevated in many cancer cells and a significant fraction is mitochondrial bound. This study examined t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gelb, B D, Adams, V, Jones, S N, Griffin, L D, MacGregor, G R, McCabe, E R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48204/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1309605/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.1.202
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